Using Runecast (great tool, more posts to come) we can see this ESXi host has been selected has 89 issues that need to be resolved:

I personally check the following before starting as these are common reasons for post remediation issues:

Cluster – Configure – Services – make sure vSphere DRS is set to Manual:

Cluster – Configure – Services -untick vSphere HA and Proactive HA:

Cluster – Configure – Configuration – VMware EVC – Enable  for the chipset you are using

Highlight the ESXi host you want to patch, then under the Update Manager tab select Scan for Updates:

Select what you want to Scan for and click OK:

Once Scan has completed Click on Stage Patches:

Select the Baselines you want to apply and then click next:

Verify the host you want to patch is selected and the click next:

Select Patches and Extensions you want to be staged and click next.

Click Finish:

Wait for the staging of patches to complete:

Click on Remediate:

Select Baselines you want to apply and click Next:

Verify the Host and click Next:

Verify that the patches selected are ones you want to install and click Next:

Options 1 and 2 is for you to decide. I choose to do this when I am available to monitor, however a lot of admins to it out of hours. Click Next:

The depends on your environment and the situation, for example you might want VMs to reboot at the same time. It is safer to leave VMs as-is for this update. Click Next:

Same as before. Click Next:

Running Pre-check Remediation is a safe way to see if you will have any issues, if you do, resolve them and come back to this step.

If you get no issues click Finish as above.

Wait for the Remediation to complete.

Check Update manager for host and it should now show it is Compliant.

Runecast still reports issues for this host, but there are a lot less to action now!